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White, BR, Padawer-Curry, JA, Cohen, AS, Licht, DJ, Yodh, AG: Brain segmentation, spatial censoring, and averaging techniques for optical functional connectivity imaging in mice. Acta Neuropathologica 2020 Notes: Under Review.Īhrens-Nicklas, RC, Tecedor, L, Hall, AF, Lysenko, E, Cohen, AS, Davidson, BL, Marsh, ED: Neuronal network dysfunction precedes storage and neurodegeneration in a lysosomal storage disorder. Kacy Cullen1,2,5: Neuronal Somatic Plasmalemmal Permeability and Dendritic Beading Followingĭiffuse Traumatic Brain Injury in Swine. Keating1,2, Daniel P.īrown1,2, Kathryn L. eNeuro 7: ENEURO, Nov 2020.įolweiler, KA, Sandsmark, DK, Diaz-Arrastia, R, Cohen, AS, Masino, AJ: Unsupervised Machine Learning Reveals Novel Traumatic Brain Injury Patient Phenotypes with Distinct Acute Injury Profiles and Long-Term Outcomes. Phys Med Biol 66: 065026, Mar 2021.įolweiler KA, Xiong G, Best KM, Metheny HE, Nah G, Cohen AS.: Traumatic Brain Injury Diminishes Feedforward Activation of Parvalbumin-Expressing Interneurons in the Dentate Gyrus. White BR, Padawer-Curry JA, Ko T, Baker W, Breimann J, Cohen AS, Licht DJ, Yodh AG.: Wavelength censoring for spectroscopy in optical functional neuroimaging. Selected Publications Mao S, Xiong G, Johnson BN, Cohen NA, Cohen AS.: Blocking Cross-Species Secondary Binding When Performing Double Immunostaining With Mouse and Rat Primary Antibodies. A better understanding of these injury-induced alterations will provide insight for directing the development of potential therapies that would ameliorate cognitive dysfunction in traumatic brain injured patients. The combination of these methodologies should help elucidate putative mechanisms causing injury-induced cognitive deficits. Immunocytochemical and biochemical techniques are used to examine specific proteins that have been altered by injury and may be underlying synaptic and/or circuit dysfunction. Excitatory and inhibitory synaptic recording is utilized to further determine the function of surviving neurons. Unbiased stereology is then used to quantify the degree of cell death. Our studies begin with conditioned fear response behavior to assess cognitive impairments and extracellular recording to evaluate injured hippocampal function. We incorporate a variety of techniques to understand the nature and functional consequences of injury-induced alterations. learning and memory and is damaged in traumatic brain injury. This system has been shown to play a primary role in higher cognitive function e.g. We are primarily concerned with alterations in neuronal excitability in the limbic system of the brain. Our principal research interest is focused on the fundamental cellular and molecular mechanisms that underlie cognitive impairments associated with traumatic brain injury. Electrophysiologic recording in neuronal cultures as well as cell lines and conditioned fear response behavior. Visualized and blind in vitro recording techniques.
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Intracellular and extracellular recording, whole-cell patch-clamp recording, immunocytochemistry, biochemistry and calcium fluorescence. Injury-induced altered brain excitability, circuit rearrangement and synaptic function Head Injury, Hippocampus, Cognitive Impairment